Human genetics of infectious diseases: Unique insights into immunological redundancy
نویسندگان
چکیده
منابع مشابه
Genetics of infectious diseases.
Infectious diseases represent a major health problem worldwide, both in terms of morbidity and mortality. A complex combination of environmental, pathogen and host genetic factors plays a role in determining both susceptibility to particular microbes and the course of infection. Numerous studies have now mapped and identified relevant genes using a variety of both family-based and population-ba...
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Rodrigo Siqueira-Batista1, Mauro Geller2 and Andréia Patrícia Gomes3 1Professor of Internal Medicine, Neuroscience and Immunology/Microbiology, Centro Universitário Serra dos Órgãos (UNIFESO); 2Professor of Immunology and Microbiology, Centro Universitário Serra dos Órgãos (UNIFESO); Coordinator of Genodermatosis, Genetic Services, Instituto Puericultura e Pediatria Martagão Gesteira (IPPMG), F...
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Five years into the human postgenomic era, we are gaining considerable knowledge about host-pathogen interactions through host genomes. This "infectogenomics" approach should yield further insights into both diagnostic and therapeutic advances, as well as normal cellular function.
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M uch of microbiological research on infectious agents is increasingly specialized and reductionist, viewing the host as a virtually static environment and thus sharply narrowing the context of the disease under study. We advocate an alternative quantitative approach that enables investigators to go beyond their reliance on conventional and somewhat simplified qualitative terms for describing e...
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ژورنال
عنوان ژورنال: Seminars in Immunology
سال: 2018
ISSN: 1044-5323
DOI: 10.1016/j.smim.2017.12.008